Coronavirus politics: The comparative politics and policy of COVID‐19

This 654-page tome might be the most comprehensive look to date at how various governments - nearly 40 in all - have sought to respond to the COVID-19 pandemic during its first 10 months, from December 2019 to September 2020. The COVID-19 pandemic has been associated with an immense growth in scientific literature, with more than 700,000 scientists publishing well over 300,000 items related to COVID-19 by the summer of 2021. Time and time again, from place to place, the COVID-19 pandemic demonstrated that extensive public health expertise from an advisory agency meant relatively little if such counsel was discounted by politicians and public health agencies lacking their own decision-making powers. [Extracted from the article] Copyright of World Medical & Health Policy is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)

Establishment of a duplex fluorescent quantitative PCR assay for detection of Porcine circovirus type 2 and type 3

To establish a method for simultaneous detection of porcine circovirus type 2 (PCV2) and porcine circovirus type 3 (PCV3), specific primers and TaqMan probes were designed after sequence alignment according to the specific sequences of PCV2 Cap gene and PCV3 Cap gene on GenBank. By optimizing the reaction conditions, a duplex fluorescence quantitative PCR detection method for simultaneous detection of porcine circovirus type 2 and 3 was established, and the specificity, sensitivity, and reproducibility were tested. Specificity test results showed that in addition to the positive test results for PCV2 and PCV3, tests for PRRSV, CSFV, PPV, PRV, PEDV, and TGEV were all negative with no cross-reaction, indicating its good specificity. Sensitivity test results showed that the minimum detection limit for detection of PCV2 and PCV3 can both reach 10 copies.L-1, indicating its high sensitivity. The coefficient of variation within and between groups of this method was less than 2%, indicating its good stability. A total of 181 pork and whole blood samples collected from Zhejiang Province were tested using the detection method established in this article and the standard common fluorescent PCR detection method. The results showed that the positive rate of PCV2 was 50.83% (92/181), the positive rate of PCV3 was 37.57% (68/181), and the co-infection rate of PCV2 and PCV3 was 12.15% (22/181). The above detection results of ordinary fluorescent PCR were 50.28% (91/181), 36.46% (66/181), and the co-infection rate was 11.60% (21/181). The coincidence rates of the two methods for PCV2 and PCV3 can reach 98.91% and 97.06%, and the coincidence rate for PCV2 and PCV3 mixed infection were 95.45%. In summary, the duplex fluorescence quantitative PCR detection method established in this experiment can distinguish PCV2 and PCV3 rapidly, which can be used for pathogen detection and epidemiological investigation.

A Documentary History of the Immunity (or Vaccine) Passport: Health Certificates of Public Health, Personal Identity and Power from the Plague to the Coronavirus Pandemic

The immunity (or vaccine) passport of the coronavirus pandemic, as a concept and object, is not unprecedented. This health and identity document features a history spanning over half-a-millennium and appearing across diverse geopolitical and sociocultural contexts. This article presents a documentary history of the immunity passport and its heterogeneous material instantiations, uses and effects across divergent historical settings. It illuminates how the immunity passport has helped shaped identities and public health, as well as impacted individual and institutional agency, during health crises. Four historical cases are explored, including the plagues ravaging the Renaissance Mediterranean region, the 1665 Great Plague of London, the yellow fever outbreaks in the antebellum slave-era southern USA and the chronic cholera conditions confronting colonial-era British India. Although disparate, these historical cases share the immunity passport as a non-pharmaceutical intervention into their respective health crises that played important roles in people's lives during these troubled times.

A Cholera Case Imported from Bangladesh to Italy: Clinico-Epidemiological Management and Molecular Characterization in a Non-Endemic Country.

Despite the number of cholera outbreaks reported worldwide, only a few cases are recorded among returning European travellers. We describe the case of a 41-year-old male, returning to Italy after a stay in Bangladesh, his origin country, who presented with watery diarrhoea. Vibrio cholerae and norovirus were detected in the patient's stools via multiplex PCR methods. Direct microscopy, Gram staining, culture and antibiotic susceptibility tests were performed. The isolates were tested using end-point PCR for the detection of potentially enteropathogenic V. cholera. Serotype and cholera toxins identification were carried out. Whole genome sequencing and bioinformatics analysis were performed, and antimicrobial resistance genes identified. A phylogenetic tree with the most similar genomes of databases previously described was built. Sample of the food brought back by the patient were also collected and analysed. The patient was diagnosed with V. cholerae O1, serotype Inaba, norovirus and SARS-CoV-2 concomitant infection. The isolated V. cholerae strain was found to belong to ST69, encoding for cholera toxin, ctxB7 type and was phylogenetically related to the 2018 outbreak in Dhaka, Bangladesh. Adopting a multidisciplinary approach in a cholera non-endemic country ensured rapid and accurate diagnosis, timely clinical management, and epidemiological investigation at national and international level.

Potential threats of cholera amidst COVID pandemic in the Democratic Republic of Congo; bridging the gaps: a review.

Cholera, being a global health issue has remarkably affected the wellness of the people, especially in the Democratic Republic of Congo (DRC). This has worsened during the COVID-19 pandemic, and it could be more if no concrete Intervention is done to curtail the outbreak. The authors reviewed past and present literatures on cholera and COVID-19 from the year 2013-2023 in well renowned scientific journals such as PUBMED, ResearchGate, Google Scholar. Database servers of these journals were accessed based on their permissions. From this search the authors found that, cholera is at its peak amidst COVID in DRC. Between the 10 March 2020 to the 10 March 2022, DRC reported a total of 86 462 cases of COVID-19 in 314 health zones in all 26 provinces of the country, with 1335 deaths recorded. And since the beginning of 2022, 6692 suspected cholera cases including 107 deaths have been reported in 54 health zones in 11 provinces of DRC, compared with 3681 suspected cases and 91 deaths reported during the same period in 2021 in 67 health zones in 14 provinces in the country. The authors realized that despite all efforts to mitigate the spread of cholera in DRC by the Congolese government and the non-governmental organizations in the country, there are still some gaps required to be filled, such as; limited community mobilizations and awareness campaigns about the signs and symptoms of cholera and COVID-19, unavailability of free cholera and COVID-19 vaccines to all the Congolese populations as well as association of witchcraft to diseases. etc. Hence, to mitigate this menace, the authors urge the Congolese government to utilize research implementation strategies such as increase mass awareness campaigns on cholera and COVID among the Congolese populations as well as training workshops for the religious and traditional leaders as well as the healthcare providers in the country for a better diagnosis and treatment of these diseases.

Peacekeeping Operations: Challenges and Opportunities in the Midst of Health Crises

The COVID-19 crisis has brought about significant challenges to international organizations operating in fragile contexts. Among others, the case of United Nations (UN) and its peacekeeping operations (PKOs) counting more than 80, 000 personnel from 121 countries is certainly prominent. Not only do PKOs rely on international personnel's frequent rotations, but they also rely on freedom of movement to carry out their mandate. How have PKOs adapted and responded to the crisis? How do PKOs balance the need to protect vulnerable civilians with support to governments' responses to the crisis and safeguard legitimacy? This chapter explores the impact of the health crisis due to the COVID-19 pandemic on PKOs by focusing on two key aspects. First, it evaluates the current PKO efforts in managing the crisis in light of two previous health emergencies occurring in the midst of PKOs, namely Ebola in Western Africa and cholera in Haiti. It will reflect on the legitimacy costs associated with the risk of UN personnel being seen as vector of the disease. Second, it identifies challenges and opportunities created by the emergency. The key challenges stem from the inevitable delay or interruption of ongoing negotiation processes, and the associated risks of armed groups taking advantage of the uncertain situation. But there are some opportunities to consider. Operational adaptation becomes a need as missions have to prioritize civilians' protection without violating governments' policies on movement. Furthermore, halting frequent personnel rotations has likely increased cohesion within missions among soldiers but also between soldiers and missions' leaders. © The Author(s), under exclusive license to Springer Nature Switzerland AG 2022.

International Law and Digital Disease Surveillance in Pandemics: On the Margins of Regulation

The COVID-19 pandemic elicited a surge in the use of digital tools to replace "classic” manual disease tracking and contact tracing across individuals. The main technical reason is based on the disease surveillance needs imposed by the magnitude of the spread of the SARS-CoV-2 virus since 2020, particularly how these needs overwhelmed governments around the world. Such developments led to stark variations across countries in terms of legal approaches towards the use of digital tools, including self-reporting software and mobile phone apps, for both disease tracking and contact tracing. Against this backdrop, in this article I highlight some of the normative challenges posed by the digitalization of disease surveillance, underscoring its almost non-existent regulation under international law. I look back at the historical emergence of the epidemiological principles underlying this procedure, by referring to John Snow's trailblazing work in cholera control. I emphasize how the COVID-19 pandemic prompted both technical and normative shifts related to the digitalization of these procedures. Furthermore, I refer to some of the overarching obstacles for deploying international law to tackle future tensions between the public health rationale for digitalized disease tracking and contact tracing, on the one hand, and normative concerns directly related to their legality, on the other hand. Lastly, I put forward conclusions in light of the current juncture of international health law reforms, and how they so far display limited potential to herald structural changes concerning the legality of the use of digital tools in disease surveillance.

Medicine Is War: The Martial Metaphor in Victorian Literature and Culture by Lorenzo Servitje (review)

Set in the twenty-first century, The Last Man was an apocalyptic story of a pandemic spreading around the world, causing the near elimination of the human population, almost literally to the last person standing. The links between public health and military medicine at this time are well-known and exemplified by Edmund Parkes's Manual of Practical Hygiene (1864). The claim that such literature had a "broader reach” in spreading the martial metaphor in medicine is questionable, without more evidence of impact.

Perceived Stress, Social Support, and Blood Pressure in Urban Haiti

Introduction: Stress is associated with multiple adverse health outcomes, including hypertension. The impact of stress on health may be moderated by social support. The distribution of stress, support, and their association with hypertension have not been well described in low-income countries that face severe poverty. Over the past decade, Haiti has suffered massive natural disasters including the 2010 earthquake, cholera outbreak, COVID-19 pandemic, and recurrent civil instability-all of which may act as prolonged stressors.Hypothesis: We assessed the hypotheses that 1) there are high levels of both stress and support in Haiti, and 2) high support would moderate the relationship between high stress and hypertension. Method(s): We measured stress and social support using validated instruments in a population-representative cohort of adults living in urban Port-au-Prince, Haiti between March 2019 and April 2021. Stress was measured using the Perceived Stress Scale, while social support was measured using the Multidimensional Scale of Perceived Social Support. For visualization, continuous scores were categorized using equal-width groups (stress: low (1-5), moderate (6-10), high (11-16);support: low (7-21), low-moderate (22-35), moderate (36-49), moderate-high (50-64), high (65-77)). Linear regression models were used to quantify the associations between: 1) stress and support adjusting for age and sex, 2) blood pressure and stress adjusting for age and sex. A formal moderation analysis was conducted to assess if support moderated the relationship between stress and blood pressure. Result(s): Among 2,817 adults, 59.7% female and the median age was 40 years (IQR 28-55). The majority had an income of less than 1 US dollar a day (69.7%). The median stress score was 8 out of 16 points, and median support score was 61 out of 77 points. Stress was higher with older ages (60+ years versus 18-29 years: +0.79 points, 95% CI 0.51 to 1.08) and in females (+0.85 points, 95% CI +0.65 to +1.06). Support was higher in males (+3.29 points, 95% CI 2.19 to 4.39). Support was inversely associated with stress, adjusting for age and sex (-0.04 points, 95% CI -0.04 to -0.03). Stress was not associated with systolic or diastolic blood pressure after adjustment for age and sex. Support did not moderate the association between stress and blood pressure. Conclusion(s): In this urban cohort of Haitian adults living with chronic civil instability, stress was moderate and support was high. While support was associated with lower stress, it did not moderate the relationship between stress and blood pressure. Despite the high levels of instability in Haiti, participants displayed resiliency through high levels of support, which may be an underutilized resource in reducing stress and long-term negative health outcomes.

On a reaction–diffusion system modelling infectious diseases without lifetime immunity

In this paper, we study a mathematical model for an infectious disease caused by a virus such as Cholera without lifetime immunity. Due to the different mobility for susceptible, infected human and recovered human hosts, the diffusion coefficients are assumed to be different. The resulting system is governed by a strongly coupled reaction–diffusion system with different diffusion coefficients. Global existence and uniqueness are established under certain assumptions on known data. Moreover, global asymptotic behaviour of the solution is obtained when some parameters satisfy certain conditions. These results extend the existing results in the literature. The main tool used in this paper comes from the delicate theory of elliptic and parabolic equations. Moreover, the energy method and Sobolev embedding are used in deriving a priori estimates. The analysis developed in this paper can be employed to study other epidemic models in biological, ecological and health sciences.

Pandemic and nationalism: from Asian morbid cholera to Chinese virus. History of the contexts of the covid-19 pandemic

From a historical, sociological, and political science perspective, and inspired by the paradigm of historical materialism, this article proposes an approach to the different contexts that circumscribe the outbreak of the Covid-19 pandemic through two types of sources: on the one hand, the bibliography, of a historiographical, sociological and epidemiological nature, in which the collection of articles published in 2020 by Rob Wallace, under the title Big farms, big flus, stands out. Agro-industries and infectious diseases, and on the other hand, the primary sources, that is, the work of analysis of the press, especially El Pais or El Mundo, the Resolutions and communications of the WHO, as well as other diverse documents, located on the internet. This macro-schematic approach defines our starting point: a reflection on questions such as:What has happened to us? What is happening to us? How can international relations be interpreted? What value does the nationalist shift occupy at the moment? And even, why have we suffered a pandemic with dramatic consequences? With this in mind, the article proposes five objectives: to analyze the epidemic structure of contemporary times, to observe the analogies between cholera morbo, influenza and Covid-19, to describe the founding process of the WHO, the role of China and the transformations of the new world order, and finally, to interpret the Chinese virus, from the context of the rebirth of nationalisms and to relate this interpretation to the Covid-19 pandemic. To develop these objectives, we propose a diachronic analysis of the different social constructions around pandemics from 1832 to 2020, likewise, we also intend to establish analogies between the different pandemics and the international relations that developed over three moments: he Asian morbid cholera (1817-34), the Spanish flu (1918-20) and Covid-19 (2020-22). In short, we will define the epidemic structure of contemporaneity. Next, as the central thesis of the work, we propose an approach to the consequences of the Livestock Revolution and climate change due to anthropogenic causes, and its relationship with human health to lead to a possible connection with the Covid-19 pandemic. This thesis needs a historical analysis in which different conditions that develop since 1970, during the third Industrial Revolution, are established. After the demographic explosion of the 1970s, during which time industrial livestock farming has been dominant in the United States, the production model soon spread to Latin America, Asia and Europe in such a way that a gradual relocation is set in motion that will accelerate during the 1990s. That is, when Eastern Europe (just like Asia or Latin America) joins the international market and offers attractive deregulation scenarios for international food industries. For this we mainly use the hypotheses of Rob Wallace and K. Shortridge: it is essential to take into account relocation tactics, industrial strategies related to the mass production of poultry meat, and the appearance of new epidemic outbreaks that affect the population since at least 1997-as well as the origin of typical pneumonia, known as SARS (Severe Acute Respiratory Syndrome) and its relationship with the coronavirus. In addition, the study of this specific context (1970-2020) allows us to understand five vital aspects to interpret the emergence of Covid-19: the decisive role of China and its policies of opening up to the market economy between 1980 and 1985, which accounted for more than one billion new consumers. In the face of this explosion in the demand for food and raw materials, millions of hectares are cleared to establish crop fields, and a large part of the planet's ecosystems are destroyed. That is why ecological arguments become one of the new contradictions in the North-South dialectic;the process of collapse of the Soviet Union supposes the rebirth of nationalisms in Europe. From 1990 to 2007, nationalisms are consolidated, grow and evolve towards populist content, useful for the different governments during the financial crisis;the signing of the North American Free Trade Agreement in 1993 between Canada, the United States and Mexico will imply the practical disappearance of the traditional model of small or medium farms in the United States and Mexico, to the benefit of vertical operations of millions of pigs and poultry. In 1998, the first outbreak of swine flu was declared in North Carolina and, later, in Veracruz;the consolidation of neoliberal economic policies (Hayek-Friedman), which support globalization and reconstruction of the new world order;and lastly, the evolution of the functions of the WHO (World Health Organization) since its foundation in 1948. This was oriented towards the cooperation and development of great health campaigns in the third world and as a factor of North-South balance until the shift presented by the secretary General Halfdan T. Mahler, who would define the goal of health for all by the year 2000. From this chronological and plot line, we lead to the financial crisis of 2007 to find the specific context in which the pandemic is declared in March 2020. On the other hand, this article deals with the effects that the outbreak and unexpected spread of a new virus has produced in the forms of (official) political communication of ethnocentric and nationalist content. These speeches raised xenophobic markings based on the rapid growth in morbidity and mortality statistics due to the new virus. So the concept of the Chinese virus, a social construction launched by Donald Trump, has configured a biased vision, successful until now, for the benefit of the West. Faced with a global problem with dramatic consequences, the response of governments will take the form of populist tactics whose objective will be the exoneration of their political, economic, social and health responsibilities. Given this situation, it will have to be the WHO that considers it essential to establish scientific criteria to refer to the mutations of the virus in order to end political stigmatization. The WHO will take the lead in naming information-neutral and information -friendly variants of interest (VOI) and variants of concern (VOC), renamed with letters of the Greek alphabet. In short, it is convenient to take into account the populist response of the different governments (United States, Brazil, France or Germany) centered on collective emotions typical of a language of war.

Effect of Hydroxychloroquine, Favipiravir, Lopinavir/Ritonavir, Remdesivir, Umifenovir, and Interferon beta-1a in Covid-19 patients: A systematic review of Randomized Clinical Trials

Background: Coronavirus disease 2019 (COVID-19) was recognized by the World Health Organization (WHO) as a global pandemic on March 11, 2020. Since then, researchers worldwide have focused their attention on identifying effective treatments and developing vaccines to combat this disease. Aim: To report the effectiveness of the drugs employed in the COVID-19 treatment protocols based on data from clinical trial studies conducted from the beginning of the pandemic until December 10, 2020. Methods: Following the PRISMA guidelines, we conducted an advanced search in several electronic databases. A total of 13553 studies was screened by two people simultaneously and separately based on the article title, and full-text. The quality of the studies was evaluated using the Cochrane criteria. Results: Of the 13553 studies identified, 50 clinical trials were included in this systematic review. Of these, three studies explored the use of remdesivir, nine studies the use of hydroxychloroquine, five studies the use of lopinavir/ritonavir, six studies the use of favipiravir, one study the use of tocilizumab, two studies the use of interferon beta-1a and two studies the use of umifenovir.

The El Dorado Pandemic

Recent experiences with COVID-19 has been a sobering reminder of how, despite advanced medical knowledge and technology- disease can scramble a society, from its economic trajectory to when and how its citizens should leave their houses. As the coronavirus's qualifying adjective notes, the experience has been novel in one sense, but in a wider context it is not. Microbes and pandemics have shaped the history of the US from its start. Early contagions opened the way to the first colonial settlements by devastating Native peoples along the Atlantic coast. In the 1780s, the smallpox that raged from Boston to the Pacific Northwest helped secure the American Revolution and open the far West to the US exploration and colonization. The global influenza pandemic of 1918 began in Kansas and claimed an estimated hundred million lives worldwide. The nineteenth century saw other pandemics. Arguably, the most dreadful was Asiatic cholera. It originated in India and spread to Europe and the US in three deadly doses--in 1832-34, in 1848-52, and in 1866-68.

Infection Diseases Following Natural Disaster in Children: Health Prevention and Assessment

[17] Diseases with a long incubation period (leishmaniasis and leptospirosis) and vector-borne diseases such as malaria and dengue should be considered as possible infections during the recovery phase (> 4 weeks) of natural disasters. [20] Outbreaks of group A streptococcus infection in camps could have devastating consequences, not just as a cause of respiratory infection, but also of wound infections. [10] In the post-earthquake period, the first wave of infectious diseases is caused by food-borne and/or water-borne infections, and/or by infections transmitted by respiratory droplets. [Extracted from the article] Copyright of Journal of Pediatric Infectious Diseases is the property of Thieme Medical Publishing Inc. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full . (Copyright applies to all s.)

Preventive Measures against Ebola and COVID-19 and Their Impact on Human Dirty-Hand Disease Mitigation in Côte d'Ivoire

Hygiene is the most useful public health measure for preventing infections of important endemic and emerging diseases of global significance. This study aimed to assess the impact of these public health preventive measures on dirty hand diseases. A retrospective survey was conducted in the rural general hospitals of Taabo (south-central Côte d'Ivoire) and Marcory (urban Abidjan) to collect clinical data on dirty hand diseases in the patients' records from 2013 to 2020. In addition, focus group discussions (N = 8) were conducted in the communities in both settings to identify the sociocultural and economic hindering or fostering factors that affected the adoption of and the compliance with handwashing and disinfection practices. A total of 3245 and 8154 patients' records were examined in the general hospitals of Taabo and Marcory, respectively. Compared with women, men were more affected by typhoid fever (OR, 0.68 [95%CI, 0.53–0.88]) and influenza (OR, 0.87 [95%CI, 0.75–1]). Hygiene measures promoted during Ebola and COVID-19 outbreaks had no impact on the prevalence of typhoid fever in both settings;however, a positive impact was observed regarding influenza infections. Populations were aware of the importance of handwashing for public health but had difficulties adhering due to financial constraints, access to drinking water, and the absence or scarcity of handwashing facilities.

COVID-19: Challenges, Preventive Measures and Remediation

This review highlights origin, symptoms, diagnosis, causative agents, mode of transmission and persistence of coronavirus disease (COVID-19) through human activities. In the current scenario researchers, doctors and scientists are striving to combat the transmission of COVID-19 among society. Origin and growth of pandemic has raised the serious concern to address the causative agents, mode of transmission, persistence, preventive measures, diagnosis and possibilities of treatment. The broad-spectrum antiviral antiphrastic, complementary and alternative medicines are currently proposed for possible eradication of the pandemic. The current world is relying on, prevention and control of infection through sanitization and quarantine and onwards waiting for appropriate virucidal agents, sanitizers and strategic vaccination and immunization to combat the pandemic of SARS-CoV-2. Eradication of COVID-19 under stringent guidelines of WHO regarding social practices, intensive care, administration of complementary medicines and innovation of vaccines are under active considerations across the world to combat the pandemic.

The Role of Active Immunity and its Types

When a pathogen activates B cells and T cells, memory B cells and memory T cells form, and the major immune response happens as a result. These memory cells "remember" every unique pathogen an animal encounters over the course of its lifetime and can develop a potent secondary response if the pathogen is discovered again. Due to the immune system's proactive self-preparation, this sort of immunity is both active and adaptable. The innate immune system and both the cell-mediated and humoral components of immunity are frequently involved in active immunity. Here, Maiorino discusses the naturally and artificially acquired active immunity.